Good move? Hard to say, although it sounds counter-intuitive to me.
Allegedly in tests users dropped the phone less often, however I'm sure that having the buttons grouped on one side of the phone (the right hand side) would reduce that risk much further.
The change allows LG to squeeze a 5.2" screen in where a 4.7" one would have fit otherwise, so there are benefits.
If you're tempted you may want to consider a fairly robust case whilst your develop new muscle memory because if ever you're going to be clumsy with something it's at its newest...